This report documents human experimentation conducted or approved by agencies of the United States government, from the earliest recorded cases in the 1830s through 2026. It is organized into two sections. The first section covers experiments that were unambiguously unethical because subjects had no meaningful opportunity to consent, were deceived about the nature of what…

The official story is simple. Lyme disease emerged naturally in the northeastern United States during the early 1970s. A bacteria called Borrelia burgdorferi had existed in North American tick populations for millennia. Changing land use patterns, deer population growth, and expanding suburban development pushed infected ticks into contact with humans. The disease was identified, named,…